Phenylpropanoids and polyketides
Medchemexpress LLC Gallocatechin gallate | 5127-64-0 | 1 MG
Gallocatechin gallate is a flavonoids product that can be isolated from the herbs of Celastrus orbiculatus. It is intended for research use only.
- Molecular weight: 458.37
- Formula: C22H18O11
- Appearance: Solid
- Color: White to off-white
- Purity: 98%
- Storage: -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light).
- Structure classification: Flavonoids
- Initial source: Plants, celastraceae, celastrus, Celastrus orbiculatus Thunb.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | MFCD00006880 | 5 G
7-Methylcoumarin is a coumarin derivative known for its potent hepatoprotective and antioxidant properties. It functions as a mechanism-based inhibitor for CYP2A6, a key enzyme involved in drug metabolism. Studies have shown that it can significantly reduce markers of liver damage, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB), in models of CCl4-induced liver injury. Additionally, it helps to restore total protein (TP) and albumin (TA) levels and prevent oxidative stress. It also exhibits an ability to decrease the mitotic activity of *A. sativum* promeristem.
- Possesses potent hepatoprotective properties
- Acts as a mechanism-based inhibitor for CYP2A6
- Reduces markers of liver damage
- Restores protein and albumin levels in serum
- Prevents oxidative stress
- Decreases mitotic activity
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 10 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* with anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This compound inhibits PKM2 with an IC50 of 2.12 μM and also inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL, respectively. 7-Hydroxyflavone is orally active.
- Isolated from *Clerodendrum phlomidis*.
- Exhibits anti-inflammatory activity.
- Protects renal cells from nicotine-associated cytotoxicity.
- Inhibits PKM2, COX-2, and 5-LOX.
- Orally active.
- Inhibits EV71 3C protease and viral replication.
- Antioxidant properties: decreases MDA and ROS, increases SOD and GSH.
- Ameliorates ischemia/reperfusion injury and neuropathic pain.
- Improves hepatic steatosis and regulates blood glucose metabolism in NAFLD models.
Medchemexpress LLC Myricetin | 529-44-2 | MFCD00006827 | 98.5% | 318.24 g/mol | C15H10O8 | 10 MG
Myricetin is an analytical reference standard of myricetin (CAS 529-44-2), a plant-derived flavonoid used as a reference material in analytical and research applications. Supplied as a high-purity solid suitable for HPLC, method validation, and quantitative analysis.
- Analytical reference standard for HPLC and method validation.
- High purity: 98.5% assay.
- Provided in small, controlled pack sizes for accurate weighing.
- Known molecular weight and formula for identification and calibration.
- Intended for research and analytical applications.
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC Eleutheroside C (Ethyl α-D-galactoside) | 15486-24-5 | 5 MG
Eleutheroside C, also known as Ethyl α-D-galactoside, is a glycoside isolated from the bulbs of Polianthes tuberosa. This white to off-white solid is intended for research use only.
- Glycoside isolated from Polianthes tuberosa
- 99.90% purity
- Molecular weight: 208.21
- Chemical formula: C8H16O6
- Appearance: Solid
- Color: White to off-white
- Classified as a saccharide
Aobious Inc iST2-1, 200MG
ABIOUS | iST2-1, 2-(4-Methoxyphenyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrrolidine | 200MG g | AOB36416-200MG | Purity: 98% by HPLC | 1019158-02-1 | MW: 378.43
Medchemexpress LLC Potassium benzoate 5kg
Potassium benzoate (Benzoic acid potassium) is a kind of biological materials or organic compounds that are widely used in life science research[1]
Medchemexpress LLC 4-Acetoxycinnamic ac 100mg
4-Acetoxycinnamic acid is an acetate ester obtained by the formal condensation of the hydroxy group of trans-4-coumaric acid with acetic acid 4-Acetoxycinnamic acid is a member of cinnamic acids and a member of phenyl acetates 4-Acetoxycinnamic acid derives from a trans-4-coumaric acid[1]
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Medchemexpress LLC Oxytetracycline dihydrate | 6153-64-6 | 99.37% | 50 MG
Oxytetracycline dihydrate is an antibiotic of the tetracycline class. It is a potent inhibitor of both Gram-negative and Gram-positive bacteria. This compound acts as a protein synthesis inhibitor by preventing the binding of aminoacyl-tRNA to the m-ribosomal RNA complex. Additionally, it exhibits anti-HSV-1 activity.
- Antibiotic belonging to the tetracycline class.
- Potently inhibits Gram-negative and Gram-positive bacteria.
- Acts as a protein synthesis inhibitor.
- Possesses anti-HSV-1 activity.
- Available in various quantities, including solid and solution forms.
- High purity of 99.37%.
Medchemexpress LLC Oxytetracycline hydrochloride | 2058-46-0 | 98.9% | 10 G
Oxytetracycline hydrochloride is an antibiotic from the tetracycline class that potently inhibits Gram-negative and Gram-positive bacteria. It functions as a protein synthesis inhibitor, preventing the binding of aminoacyl-tRNA to the m-ribosomal RNA complex. Additionally, it exhibits anti-HSV-1 activity.
- Antibiotic from the tetracycline class
- Potently inhibits Gram-negative and Gram-positive bacteria
- Functions as a protein synthesis inhibitor
- Exhibits anti-HSV-1 activity
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mM (in 1mL DMSO)
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 500mg
Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies